Tropomyosin isoform switching in tumorigenic human fibroblasts.
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چکیده
منابع مشابه
Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.
We isolated a cDNA clone from the tumorigenic human fibroblast cell line HuT-14 that contains the entire protein coding region of tropomyosin isoform 3 (Tm3) and 781 base pairs of 5'- and 3'-untranslated sequences. Tm3, despite its apparent smaller molecular weight than Tm1 in two-dimensional gels, has the same peptide length as Tm1 (284 amino acids) and shares 83% homology with Tm1. Tm3 cDNA h...
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Tropomyosins (Tm) are a large family of isoforms obtained from multiple genes and by extensive alternative splicing. They bind in the alpha-helical groove of the actin filament and are therefore core components of this extensive cytoskeletal system. In non-muscle cells the Tm isoforms have been implicated in a diversity of processes including cytokinesis, vesicle transport, motility, morphogene...
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1 Department of Plant Systems Biology, VIB, Technologiepark 927, B-9052 Gent, Belgium (D.V., K.V.), Department of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium (D.V., K.V.) 2 Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, North Carolina Research Campus, Kannapolis, NC 28081, USA (A.R.E, Y.C.L., A.E.L) C...
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In an analysis of 12 human fibroblast cell lines by two-dimensional electrophoresis, one cell line (1493) was found to contain a major protein variant (Cytosk: 12; for the convention used in spot numbering, see Anderson, N. L. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 2407-2411) not present in any of the other 11 cell lines. Biochemical characterization of the variant protein included determin...
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We have isolated a cDNA clone from a human fibroblast cDNA library that contains the entire protein-coding region of a 1.1-kilobase mRNA. This mRNA encodes a 284-amino acid tropomyosin, the primary structure of which most closely resembles smooth muscle tropomyosin. Thus, the expression of both 284-amino acid muscle-type and 247-amino acid non-muscle-type tropomyosins appears to be a normal fea...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1986
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.6.7.2721